The mission of the Yuzawa Laboratory is to create high-value compounds that cannot be achieved through conventional chemistry by leveraging synthetic biology. Traditional organic synthesis often faces significant challenges in efficiently producing large, structurally complex molecules containing multiple stereocenters. In contrast, synthetic biology harnesses the remarkable catalytic precision of biological systems, enabling the production of structurally diverse and highly stereochemically defined molecules with molecular weights ranging from approximately 100 to 1,000.

Our laboratory engineers and redesigns megasynthases, including polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs), and precisely integrates their corresponding biosynthetic gene clusters into microbial genomes to establish innovative biosynthetic pathways. This engineered megasynthase platform not only enables the production of novel high-value compounds but also provides a sustainable approach for manufacturing commodity chemicals from renewable feedstocks.

By integrating our proprietary long DNA synthesis and editing technologies, for which patent applications have been filed, with advanced megasynthase engineering, together with the biofoundry expertise and experience cultivated in the United States, the Yuzawa Laboratory aims to establish next-generation microbial production platforms. Through these efforts, we seek to create molecular architectures that are inaccessible through conventional approaches while advancing sustainable biomanufacturing for a future bio-based society.